Sae (Fatal Frame 2 / Project Zero 2)
Alex Mercer (Prototype)
Alex Mercer is a disease-based mutagenic organism that reanimated the corpse of a scientist that dropped a vial of it on the ground just before being killed and collapsing on the shattered vial. The virus consumed Alex's corpse, reanimating his body in the process, using his cells to preserve its existence and creating a new entity with inhuman and assimilation abilities. While he's technically the protagonist of the game, and kind of falls under the mantle of anti-hero as he strives to halt the infection and save Manhatten Island from being nuked, his methods are anything but heroic as he consumes and absorbs random and not-so-random humans, murders hundreds, and at times assists the virus in his own need to learn what he needs to know. He's slightly emo about it all, which provides a little emotional depth, but his little shots of angsty irritation at the evil men who did this to him seems a little alien when you compare it to what he's happy to do himself! A delightfully convoluted bad guy and an alien mind to boot. What a guy!
The Faustian Devil (Many).
More of an archetype than a character but still my favourite. This is the evil con artist with the welcoming smile. This person is clever and cunning, though not very wise, and often will end up over-playing his hand. He'll play to the hero's faults, enshrining them, developing them, helping them grow, and thus is a lot of fun. He also tends to be at ease with himself, genuinely happy with his situation (at least while the going is good), and eager to gain more. What can I say? I like happy, conniving bad guys. Too much angst is bad for the skin.
And that's it for the ones off the top of my head. I'll start taking a look around, read a few more books, and do the next five over the next few months because - sadly enough, I've just realised that there are too few bad guys of interest for me to learn from.
So, do you guys have any suggestions of books I should read to find some of your favorite villains?